Invitrogen
Filed by INVITROGEN
Pursuant to Rule 425 under the Securities Act of 1933
and deemed filed pursuant to Rule 14a-12
of the Securities Exchange Act of 1934
Subject Company: APPLIED BIOSYSTEMS
Commission File No. : _____-______

June 12, 2008

Dear Customer,

I am pleased to inform you that on June 12, 2008 we announced that Invitrogen and Applied Biosystems will combine to create a global leader in biotechnology reagents and systems. We believe our highly complementary product and service offerings will allow us to accelerate and drive new discoveries and commercial applications. The combined company will have a major presence in key growth markets and exceptional technical capabilities in the areas of genetic analysis, proteomics, cell biology and cell systems.

We are very excited about the combination of our two companies, which we believe will allow us to bring you a vast array of quality consumables and instruments, new advanced technologies, and access to an industry-leading team of approximately 3,000 sales and service employees. Furthermore, the company will have significant R&D resources and a shared culture of innovation, which we believe will serve as the basis for strengthening our portfolio and providing you more comprehensive solutions for your technology development and specific research needs.

We are targeting to close the transaction in the fall of 2008. In the meantime, there will be no change in your current ordering practices for Invitrogen products. Should there be any change to your service or representation when the transaction is completed, we will inform you in advance. As always, we are committed to providing you with the same quality and commitment you've come to expect from Invitrogen over the years.

We believe the combination of Invitrogen and ABI will help us to better meet your needs. We look forward to building upon our relationship with you and hope you share our enthusiasm about our exciting future. We appreciate the confidence that you have put in us and will continue to work hard to earn your trust.

For future updates, please visit our website at http://www.uptilt.com/c.html?rtr=on&s=hfi,108p4,1juk,c5qk,78sa,dcw7,82ke.

Sincerely,

Bernd Brust

Bernd Brust
Senior Vice President, Global Sales & Marketing


FORWARD-LOOKING STATEMENTS
Certain statements contained herein are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, and Invitrogen and Applera intend that such forward-looking statements be subject to the safe harbor created thereby. Forward-looking statements may be identified by words such as "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," "will," or words of similar meaning and include, but are not limited to, statements about the expected future business and financial performance of the Applied Biosystems Group of Applera, Invitrogen and the combined company. Such forward-looking statements include, but are not limited to, statements relating to financial projections, including revenue and pro forma EPS projections; success in acquired businesses, including cost and revenue synergies; development and increased flow of new products; leveraging technology and personnel; advanced opportunities and efficiencies; opportunities for growth; and expectations of prospective new standards, new delivery platforms, and new selling specialization and effectiveness. A number of the matters discussed herein that are not historical or current facts deal with potential future circumstances and developments, in particular, information regarding the new company, including expected synergies resulting from the merger of Invitrogen and Applera, combined operating and financial data, future research and development plans and whether and when the transactions contemplated by the merger agreement will be consummated. The discussion of such matters is qualified by the inherent risks and uncertainties surrounding future expectations generally and other factors that could cause actual results to differ materially from future results expressed or implied by such forward-looking statements. Such risks and uncertainties include, but are not limited to: the failure to realize capital and operating expense synergies; the result of the review of the proposed merger by various regulatory agencies, and any conditions imposed on the new company in connection with consummation of the merger; approval of the merger by the stockholders of Invitrogen and Applera and satisfaction of various other conditions to the closing of the merger contemplated by the merger agreement; and the risks that are described from time to time in Invitrogen's and Applera's respective reports filed with the SEC, including Invitrogen's annual report on Form 10-K for the year ended December 31, 2007 and quarterly report on Form 10-Q for the quarter ended March 31, 2008 and Applera's annual report on Form 10-K for the year ended June 30, 2007 and quarterly reports on Form 10-Q for the quarters ended September 30, 2007, December 31, 2007 and March 31, 2008, as such reports may have been amended. This document speaks only as of its date, and Invitrogen and Applera each disclaims any duty to update the information herein.
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